What is Inchemicotox?
This is the website of the DEFRA LINK Alternatives to Animal Testing for Chemical Risk Assessment Project. The practical phases of the project (2006 – 2010) have now been completed and the results of the project are available here.
The Project was funded by the United Kingdom Department for Environment, Food and Rural Affairs (Defra) and co-ordinated by Liverpool John Moores University. The project aims were to develop non-animal toxicity testing methodologies for the risk assessment of chemicals. Specifically, these activities focused on alternatives for acute fish toxicity testing and for skin sensitisation testing.
The project was sponsored by Defra through the Sustainable Arable Link Programme (Project Number LK0984).
The inchemicotox project brought together alternatives to the use of animals in toxicological assessment to develop Integrated Testing Strategies (ITS) and tools for the risk assessment of chemicals. The structure of the project is described in more detail below.
The following tasks were completed:
- Toxicological information for skin sensitisation and fish acute toxicity were collated. This information was obtained from the open literature (including a variety of internet sources) and was supplemented with information from European Union and other National and International Projects.
- In silico tools, such read-across and (quantitative) structure-activity relationships (Q)SARs were developed further for the prediction of reactive toxicity (e.g. excess acute fish toxicity, skin sensitisation).
- In vitro methods and the use of surrogate (lower) species were evaluated for the successful prediction of toxicological effects. This included the development of the use of surrogate species (such as the TETRATOX and Microtox tests). Prediction Models (PMs) to extrapolate information from a lower species (such as a microorganism) to a higher species (such as a vertebrate) were developed.
- Mechanisms of toxic action for skin sensitisation and acute fish toxicity were determined. This included the extension of existing approaches based on chemical reactivity to make them suitable for integration into the testing strategies.
- Integrated testing strategies for risk assessment developed here and elsewhere e.g. the REACH Implementation Projects (RIPs), EU 6th Framework Integrated Projects etc. were assessed.
June 18th, 2012
Software downloads now available
Eco-Derek and ITS strategy software are now available to download from the software section of the inchemicotox.org site. Read more…
September 16th, 2010
Inchemicotox launches improved website
To coincide with the dissemination workshop at Leeds Armouries on the 17th of September, the inchemicotox project is pleased... Read more…
August 12th, 2010
Workshop on Alternatives to Animal Testing – September the 17th 2010
We are presenting the results of the Inchemicotox project at a one-day workshop on Friday the 17th of September. ... Read more…
Read more about the Software Downloads available from inchemicotox.org, including the ITS Tool.
Please click here to go to our results page where you are able to download all the Inchemicotox results.
Please click here to go to our Dissemination pages:
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